The participants’ quality of life, both physical and emotional, also improved, resulting in fewer hospitalizations.1 Later studies showed that the program is also effective for adults of all ages with epilepsy.2,3, PEARLS Toolkitexternal icon Some cardiac arrest patients without ST elevation on their ECGs may be having a heart attack, but uncertainty remains about the best approach for their care. At 12 and 18 months, participants assigned to PEARLS had significantly lower HSCL-20 scores for overall depression severity (p<0.05) and lower suicidal ideation (measured by two HSCL-20 items) (p<0.025) than did participants in usual care.1,2. Coronary angiography (also known as heart catheterization, or heart cath) is typically performed for patients with cardiac arrest due to a heart attack with ST elevation on their ECGs. The PEARLS program is an outgrowth of a five-year research project conducted in collaboration with the University of Washington’s Health Promotion Research Center (HPRC). The principal investigator for the PEARL study at Mayo Clinic is Jacob C. Jentzer, M.D., a consultant in cardiovascular diseases and pulmonary and critical care medicine at Mayo Clinic, Rochester, Minnesota. Ciechanowski P, Chaytor N, Miller J, et al. Because the intervention is home-based, it holds promise in treating depression in people with diseases or conditions associated with loss of mobility and independence. Review the PEARL Q & A information sheetto learn more about the EFIC process. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Advertising and sponsorship opportunities. The PEARL study will help answer the question, "Does an early heart cath improve survival and prevent heart muscle damage after a cardiac arrest without ST segment elevation on the ECG?". For participants whose mood did not improve after 4–5 weeks, the team psychiatrist contacted the participant’s neurologist about potential changes in depression medication. Is delivered in the client’s home or other accessible community setting 3. Further, because PEARLS can be implemented as part of existing community social services programs, eligible people can be readily identified and enrolled. Assessments of level of depression (measured by the Hopkins Symptom Checklist [HSCL-20]), quality of life, and suicidal ideation were conducted in each participant’s home at baseline and then by telephone at 6, 12, and 18 months by blinded interviewers. The PEARL study is a clinical trial evaluating the safety and effectiveness of coronary angiography (also known as heart cath) performed within 120 minutes of hospital arrival in a population of post-cardiac arrest patients without ST segment elevation on their electrocardiograms (ECGs). Is designed to be delivered in the community through social service or other trusted community-based organizations 4. Depression affects 30%–50% of people with epilepsy and contributes to their much higher unemployment, lower quality of life, and 5- to 25-times higher suicide rate than the general population.1 Studies have shown that depression is suboptimally treated in people with epilepsy and that interventions are needed.1. Study participants assigned to the PEARLS program had significantly lower scores for overall depression and lower levels of suicidal thoughts. Ciechanowski P, Wagner E, Schmaling K, et al. PEARLS is a home-based intervention for older adults that has been shown to significantly decrease depression and improve functional and emotional well-being.