Intake expressed as µg/person per day calculated as follows: [(annual volume, kg) x (1 x 109 µg/kg)/ (population x survey correction factor x 365 days)], where population (10%, ‘eaters only’) = 32 x 106 for Europe and 26 x 106 for the USA. All members of this group are aromatic primary alcohols, aldehydes, carboxylic acids, or related esters or acetals. Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide, Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem. The natural occurrence and total annual production of these are discussed in sections 1.1 and 1.2, respectively, and summarized in Table 2. Toxicol., 26, 487–500. No histopathological examination was performed (Oser, 1957). National Toxicology Environ. Benzene itself is a good solvent for many organicand inorganic substance4. Benzene & Its Derivatives Chapter 22 Organic Lecture Series 2 Reactions of Benzene The most characteristic reaction of aromatic compounds is substitution at a ring carbon: + + Chlorobenzene Halogenation: H Cl2 Cl FeCl3 HCl + + Nitrobenzene Nitration: HNOHNO3 2 H2 SO4 H2 O. Organic Lecture Series 3 + Benzenesulfonic acid Sulfonation: HSOSO3 3 H H2 SO4 + + An alkylbenzene Alkylation: RX R … 13. J., 52, 423–430. In the opinion of the Committee, the endogenous concentration of this substance would not give rise to perturbations outside the physiological range. (1948) Toxicological investigations of compounds proposed for use as insect repellents. Only the results of studies on the flavouring agents in the group that were not reported at the forty-sixth meeting are presented below. 2Clinical Pharmacology Group, University of Southampton, Southampton, United Kingdom Cotruvo, J.A., Simmon, V.F. Benzyl formate. Environ. The Structure of Benzene • In the resonance hybrid, the six electrons from the three π-bonds are delocalized over the entire ring. Mutag., 5, 419 (Abstract Cd-19). & Loveday, K.S. Arene A term used to describe aromatic compounds. Unpublished report. 22) to 12 000 mg/kg bw for hexyl benzoate (No. At its forty-sixth meeting, the Committee evaluated the five benzyl derivatives as a group and maintained the group ADI of 0–5 mg/kg bw as benzoic acid equivalents (Annex 1, reference 122). c. Parasympathomimetics, Parasympatholytics, Sympathomimetics, sympatholytics. Unpublished report No. Mutag., 17, 196–219. 850) were reviewed by the Committee at its forty-sixth meeting (Annex 1, reference 122). Submitted to WHO by Flavor and Extracts Manufacturers Association of the United States. Rudd, C.J., Mitchell, A.D. & Spalding, J. Rapson, W.H., Nazar, M.A. Owen, G. & Meyer, F. (1971) Acute oral toxicity investigation in rats. J., 48, 88–96. (1980) Screening of tobacco smoke constituents for mutagenicity using the Ames test. Micromeretics: Particle size and distribution, mean particle size, number and weight, distribution, particle number, methods for determining particle size by different, methods, counting and separation method, particle shape, specific surface, methods for. (1974) Acute oral toxicity in rats. Submitted to WHO by Flavor and Extracts Manufacturers Association of the United States. (1989) An evaluation of food flavoring ingredients in a genetic toxicity screening battery. International Organization of the Flavor Industry (1995) European inquiry on volume use. Mutat. Cuminaldehyde (No. At high doses, the formation of the glycine conjugate is limited; when glycine is depleted, free benzoic acid may sequester acetyl coenzyme A or be excreted unchanged or as the glucuronic acid conjugate. Perfumer Flavorist, 12, 27. 10/10 Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B. Ring Analogues of Phenothiazeines: Chlorprothixene, Thiothixene. Biosynthesis and catabolism of acetylcholine. The group also includes seven additional structurally related benzyl derivatives (Nos 863–869) containing ring alkyl substituents.